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For humans, the human brain is the organ with the highest content of phosphatidylserine (PS), accounting for about 18% of all phospholipids in the brain. Compared to other phospholipids, PS is the only negatively charged cytoplasmic membrane phospholipid, and this special property determines its important function: to form specific anchoring points on the inner membrane of nerve cells. These anchor points are necessary for nerve cells to perform normal functions. In addition, PS is also the only phospholipid that can regulate the functional status of key proteins in cell membranes.

Phosphatidylserine is composed of a hydrophilic glycerol backbone at the head and an oleophilic group of two longer chain hydrocarbons at the tail. Phosphatidylserine can maintain and repair nerve cells, enhance the activity of nerve growth factors in the central nervous system, promote the generation of acetylcholine, stimulate the release of dopamine, and provide sufficient signals for regulating adaptive immune responses.

Research has shown that phosphatidylserine can quickly enter the brain through the blood-brain barrier after absorption, soothing vascular smooth muscle cells, increasing brain blood supply, improving nerve cells, and regulating nerve pulse transmission. Using soybean phospholipids as natural raw materials and innovative enzymatic reaction technology, phosphatidylserine is efficiently and gently produced, rather than using traditional chemical synthesis methods. This enzymatic reaction utilizes specific biological enzymes to catalyze the molecular transformation of soybean phospholipids, resulting in the precise generation of phosphatidylserine. This method not only ensures the natural purity and biological activity of the product, but also greatly improves production efficiency and product quality. Choosing soy phospholipids as raw materials is not only due to their abundant and renewable sources, but also because their unique composition makes enzymatic reactions more efficient. Our production method not only meets the market's demand for natural and safe products, but also injects new vitality into sustainable development and environmental protection.

Natural phospholipids

Phosphatidylserine

Phosphatidylethanolamine

Phosphatidyl ethanolamine (PE) is the second highest content of phospholipids in living organisms after PC, and is also known as brain phospholipids due to its rich expression in the brain and spinal cord.

Cerebrophospholipids are excellent natural surfactants with unique biological and physiological functions, and are non-toxic, non irritating, and do not cause environmental pollution. Therefore, they have received high attention from domestic and foreign scholars. A phospholipid composed of glycerol, fatty acids, phosphoric acid, and ethanolamine. It exists in the brain, nerves, soybeans, etc. Fresh products are colorless solids that can easily turn reddish brown in the air. Has hygroscopicity. Insoluble in water and acetone, slightly soluble in ethanol, soluble in chloroform and ether. Can be used as an antioxidant.

Phosphatidyl ethanolamine can form a non bilayer of phospholipids, which is a multifunctional phospholipid essential for mammalian development, accounting for 15% -25% of the total phospholipids in mammalian cells. In the study by GuanZ et al. on the phospholipid content in the brain of Alzheimer's patients, it was found that the content of phosphatidylethanolamine in the frontal lobe of patients was significantly reduced.

The liver is the main site for lipid synthesis, and PE is closely related to the occurrence and development of liver diseases. The ratio of PC/PE is crucial for the integrity of liver cells. PE is also related to the secretion of liver bile.

Using a unique extraction method, high-quality soybean phospholipids are used as natural raw materials to efficiently extract phosphatidylethanolamine, rather than through chemical synthesis. This method not only ensures the purity and biological activity of the product, but also better preserves the original nutritional value and bioavailability of phospholipids. Soybean phospholipids, as a rich and renewable natural resource, provide us with a large amount of high-quality phospholipid precursor substances, making the extraction of phosphatidylethanolamine more economically feasible. By extracting rather than synthesizing, our produced phosphatidylethanolamine not only meets the needs of consumers for natural and healthy products, but also contributes to promoting sustainable development and environmental protection.

Herbal extract

Siraitin

Momordica grosvenorii glycoside, also known as momordica grosvenorii glycoside and momordica grosvenorii glycoside, is extracted from Momordica grosvenorii, a special economic plant in Guangxi. It is a sweet ingredient of Momordica grosvenorii. Its sweetness is 300 times that of sucrose, and its heat is zero. It has the effects of clearing heat, moistening the lungs, relieving cough, moistening the intestines, and relieving constipation, and preventing obesity, diabetes.

The study found that when the oral dose of mogroside was more than 15g/kg, it could reduce the cough frequency, increase the amount of tracheal secretion, and have obvious antitussive and expectorant effects. In addition, momordica grosvenorii glycosides can inhibit respiratory inflammation. When studying the effect of siraitin on the growth of Streptococcus mutans, it was found that Streptococcus mutans almost did not grow and reproduce in the culture medium containing siraitin, indicating that siraitin has strong antibacterial activity.

Expectorant and cough relieving, anti-inflammatory and antibacterial

Clearing free radicals and antioxidant properties

Momordica grosvenorii glycoside has antioxidant function, and has certain scavenging effect on hydroxyl free radicals and superoxide anion free radicals. With the increase of the concentration of momordica grosvenorii glycoside extract, the scavenging effect gradually increases, showing a certain dose effect relationship. The research indicated that momordica grosvenorii glycosides could significantly increase the activities of GSH Px and SOD in serum (P<0.05), and significantly reduce the content of MDA in serum (P<0.05), indicating that momordica grosvenorii glycosides have strong antioxidant effects.

Lowering blood sugar

Siraitia grosvenorii glycoside is a safe sweetener that does not affect the blood sugar content of normal people, and has a significant inhibitory effect on postprandial blood glucose production. In addition, momordica grosvenorii glycoside has a preventive and therapeutic effect on the abnormal increase of serum triacylglycerol and serum cholesterol in diabetes patients, can increase the content of serum high-density lipoprotein cholesterol, the blood lipid level of the body tends to be normal, and prevent the disorder of lipid metabolism caused by diabetes.

Protecting liver and anti-cancer

In the experimental study on the protective effect of siraitia grosvenorii glycosides on experimental liver injury, it was found that siraitia grosvenorii glycosides could increase the activity of superoxide dismutase (SOD) in liver tissue homogenate, reduce the content of malondialdehyde (MDA), significantly reduce the degree of pathological changes in liver tissue, and have a protective effect on immune liver injury. It can also inhibit the activation of key cells in liver fibrosis - hepatic stellate cells, promote their apoptosis, and exert anti liver fibrosis effects. It was found that momordica grosvenoris glycosides could inhibit the early antigen of EBV induced by tumor promoter TPA, and the mechanism was to inhibit the production of liver cancer by inhibiting the expression of gene Cyp1a1.

Enhance immunity

Momordica grosvenorii glycoside has the physiological activity of enhancing immunity and the pharmacological activity of protecting and regulating immune function. In addition, momordica grosvenorii glycosides also have the function of positively regulating the metabolism of body lipids, delaying its aging, and also have a certain role in anti sports fatigue, anti sports immune dysfunction and other fields.

Dihydromyricetin

Dihydromyricetin, also known as dihydromyricetin, dihydromyricetin, snake grape extract, etc., with a chemical formula of C15H12O8, is an extract of snake grape leaves and the main active component of flavonoids in rattan tea.

Antibacterial effect

Pharmacological experiments have shown that dihydromyricetin has antibacterial effects on Bacillus subtilis, Staphylococcus aureus, Salmonella, Escherichia coli, Pseudomonas aeruginosa, beer yeast, red yeast, Penicillium, Aspergillus niger, Aspergillus flavus, Mucor, and Rhizopus, especially on Gram positive, Gram negative cocci or bacteria.

The regulatory effect on blood sugar and blood lipids

Pharmacological experiments in mice by gavage showed that dihydromyricetin can significantly inhibit the increase in blood sugar induced by alloxan, adrenaline, streptomycin, etc., while increasing serum insulin levels. Lymphocyte infiltration in pancreatic tissue is significantly reduced, inflammatory response is significantly reduced, and the number of pancreatic islets is significantly increased. Dihydromyricetin has a reducing effect on serum triglyceride (TG) levels in streptozotocin-induced hyperglycemic rats, but has no significant effect on serum total cholesterol (TC) and high-density lipoprotein cholesterol (HDL2C) levels.

Hepatoprotective effect

Dihydromyricetin has a significant protective effect on carbon tetrachloride induced liver injury in cultured rat liver cells, as well as D2 galactosamine and lipopolysaccharide induced liver injury in mice. Dihydromyricetin can protect the liver, accelerate the rapid decomposition of ethanol metabolite acetaldehyde, turn it into a non-toxic substance, and reduce its damage to liver cells. In addition, dihydromyricetin can improve the increase in serum lactate dehydrogenase activity caused by liver cell damage, inhibit the formation of collagen fibers in hepatic M cells, and thus play a protective role in the liver, significantly reducing the damage of ethanol to the liver, and quickly restoring the normal state of the liver. Microherb experiments have shown that dihydromyricetin can protect the liver, accelerate the rapid decomposition of ethanol metabolite acetaldehyde, and become non-toxic substances, reducing damage to liver cells. Dihydromyricetin has a rapid and long-lasting effect, making it a good product for protecting the liver, relieving alcohol and sobering up.

Antioxidant effect

Dihydromyricetin with a purity of 98% can significantly inhibit the generation of malondialdehyde (MDA) in rat myocardial, liver, and brain tissue homogenates, and its inhibitory effect increases with the increase of Dihydromyricetin concentration. Dihydromyricetin with a content of 99% has a scavenging effect on diphenyltrinitrophenylhydrazine (DPPH) free radicals in the experimental system. Dihydromyricetin can significantly inhibit the generation of MDA in oils and fats, and its antioxidant effect increases with the increase of Dihydromyricetin purity (60% -90%); It has strong antioxidant effects on both animal and vegetable oils.

Antitumor effect

Several years of anti-tumor pharmacological research have found that one of its active ingredients, the small molecule compound of ampelopsin, has a relatively strong anti-cancer effect. In vitro and in vivo anti-tumor studies have found that this compound can improve the therapeutic effect of tumors and improve the patient's vital signs by inhibiting tumor vascular growth, regulating and enhancing cellular immune function. It has shown significant anti-tumor effects in tumor model experiments such as leukemia and nasopharyngeal carcinoma.

Root bark glycoside

Root bark glycoside is the glucoside of root bark extract. It belongs to the dihydrochalcone class of flavonoids, with the molecular formula C21H24O10.

Root bark glycoside is a glycoside synthesized by the combination of root bark extract and glycoside, which hydrolyzes sugar groups to form glucose. In addition to its high content, it is considered by many scholars to be a storage form of carbohydrates. 4-deoxygenated root bark glycosides have also been widely studied and applied. Its degradation product, root bark phenol, can effectively inhibit microbial activity.

Antibacterial activity

Antioxidant

Various flavonoids have a certain degree of elimination of superoxide anion O ˉ The action of second-class free radicals. This antioxidant capacity comes from the hydrogen or electron donating ability of its phenolic hydroxyl groups. Root bark glycoside is a glycoside derivative of dihydrochalcone root bark glycoside. Dihydrochalcone is one of the members of flavonoids, which has certain antioxidant properties and characteristics. Although the molecular structure of root bark glycoside is weakened by 2 '- hydroxyglycosylation, its comprehensive antioxidant capacity is still higher than that of VC and VE, and it has a unique antioxidant mechanism. In addition, root bark glycosides can be hydrolyzed in the body to remove glycosidic groups and generate root bark glycosides, which have better antioxidant capacity.

Treat diabetes

The tender leaves of Polysaccharides are rich in phloridzin. Recent studies have found that phloridzin has some unique functions and has a good preventive and therapeutic effect on diabetes and its complications. This paper reviews the research progress in this field at home and abroad, with a view to providing some help for the development and utilization of phloridzin. Rhizoside specifically and competitively inhibits the transport of glucose molecules by SGLT1 and SGLT2. It has been confirmed in several animal models that root bark glycosides can promote glucose secretion, reduce fasting and postprandial blood glucose levels, and do not cause hypoglycemic side effects. Treatment of diabetes rats with phloridzin can make their insulin sensitivity return to normal, and eliminate or reduce insulin resistance caused by glucose toxicity.

Improving memory ability

The activity of the brain consumes a large amount of energy supplied by glucose, and there is evidence that circulating blood sugar levels control the process of learning and memory. The effects of many drugs that improve memory ability are related to the ability to release liver glycogen, increase brain blood sugar levels, and utilize them. Root bark glycoside inhibits blood sugar from entering the brain. Therefore, the mechanism by which ginsenosides enhance the memory ability of the brain is clearly independent of blood glucose levels or the brain's ability to absorb sugar.

chlorogenic acid

Chlorogenic acid, also known as coffee tannic acid or Eucommia ulmoides chlorogenic acid, is a natural polyphenolic compound with the chemical formula C16H18O9. It is extracted from the natural plant burdock root. It has extensive applications in fields such as medicine, daily chemical industry, and food.

Protecting cardiovascular function

Oxygen free radicals can cause damage and apoptosis of endothelial cells in vascular walls, which is an important factor leading to many cardiovascular diseases. Research has shown that chlorogenic acid has free radical scavenging and antioxidant effects. Chlorogenic acid can to some extent inhibit endothelial cell apoptosis caused by hydrogen peroxide.

Hypoglycemic effect

Chlorogenic acid can prevent the occurrence of diabetes to a certain extent. The study shows that chlorogenic acid can significantly improve insulin resistance in type 2 diabetes rats. The mechanism of glucose transport to skeletal muscle can be regulated to some extent by affecting insulin content.

Lipid-lowering effect

Chlorogenic acid can effectively prevent obesity and related metabolic syndrome caused by diet. Paraguay tea extract can significantly reduce the levels of triacylglycerol and cholesterol in rat plasma, in which chlorogenic acid plays an important role. It has also been pointed out in research that chlorogenic acid can regulate cholesterol metabolism by inhibiting the activity of hydroxymethylglutaryl CoA reductase.

Antibacterial and antiviral effects

Chlorogenic acid has a significant inhibitory effect on the capsule synthesis of Streptococcus maltophilus organisms, and it is believed to be a safe synthetic antibacterial drug or a combination of antibiotics for the treatment of Streptococcus maltophilus infection. Chlorogenic acid can adsorb onto bacterial cell membranes, leading to bacterial cell death. Chlorogenic acid can significantly inhibit the replication of hepatitis B virus DNA, thus inhibiting the growth and reproduction of hepatitis B virus.

Antileukemia effect

Research has found that chlorogenic acid has certain anti leukemia activity and can induce apoptosis of Bcr-Abl positive cells in chronic myeloid leukemia. It has a significant destructive effect on chronic myeloid leukemia cell line K562.

Root bark glycoside is extracted from the Eucommia ulmoides, with a sweetness 300 times that of sucrose and a calorific value only one-third of sucrose.

The chlorogenic acid in coffee can improve the oxidative state of the colon, thereby reducing the risk of rectal cancer.

Anti mutagenic and anticancer effects

Chlorogenic acid also has pharmacological effects such as anti complement, affecting the concentration of trace elements in plasma, and enhancing immunity.

Other functions